Beam is seeking a motivated individual to join our lead discovery and off-target biology group. The successful candidate will contribute to our ongoing efforts to assess the totality of the genome-modifying potential of our next-generation base editing technology. Candidates should be highly self-motivated with the ability to excel in a fast-moving and goal-oriented environment.
Develop, design, optimize and execute assays to assess the genome-modifying potential of base editors.
Support off-target editing risk assessment for different projects.
Next-generation sequencing (NGS) library preparation and sequencing.
Mammalian cell culture and transfection.
Maintain detailed documentation of experiments in ELN system.
Coordinate and work with other teams at Beam in a highly matrixed environment.
Data analysis to visualize outcomes of genome editing.
PhD in a cell biology, molecular biology, genetics or other relevant field.
Industry experience is preferred.
Demonstrated mastery of NGS including DNA/RNA sequencing library preparation and quantification, familiarity with Illumina sequencing platforms e.g. Miseq, and extensive experience in molecular biology and cell biology (DNA/RNA extraction, PCR, qPCR, ddPCR, cell culture and transfection).
Experience with assay development is preferred.
Knowledge of genomics, gene editing tools and Experience with basic sequencing data analysis is preferred but not required.
Excellent troubleshooting and multi-tasking skills, attention to detail and ability to work independently and collaboratively are required.
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