Department of Health and Human Services
National Institutes of Health
National Institute on Aging
Intramural Research Program
Center for Alzheimer’s and Related Dementias
The National Institute on Aging (NIA) Intramural Research Program (IRP), a major research component of the National Institutes of Health (NIH) in the Department of Health and Human Services (DHHS), is seeking applications from highly motivated individuals for the position of Tenure-Track Investigator 1 in the Center for Alzheimer’s and Related Dementias (CARD), located in Bethesda, MD.
CARD is a collaborative initiative between the NIA and the National Institute of Neurological Disorders and Stroke (NINDS) that supports basic, translational, and clinical research on Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) including AD, Dementia with Lewy Bodies, Frontotemporal Dementia, and Vascular Dementia. CARD’s central mission is to initiate, stimulate, accelerate, and support research that will lead to the development of improved treatment and prevention for these diseases. The new Center, which features a state-of-the-art facility and cutting-edge technology, serves as a collaborative hub for research in the AD/ADRD space, leveraging the highly collaborative and collegial nature of the Intramural Research Program.
The successful candidate will develop an independent research program focused on one or both of the two research areas detailed below, each directed toward an understanding of AD/ADRD.
Thematic area one: Modern molecular neuropathologic research that aims to investigate the basis of AD/ADRD using human-derived samples. The successful candidate will launch an independent research program that integrates standard neuropathological approaches with state-of-the-art methods, such as digital neuropathology, and artificial intelligence-based classification, to characterize the molecular basis of neuropathologic human tissue including bulk, single cell, and spatial genomics, transcriptomics, and proteomics. The successful candidate will be expected to conduct research in close collaboration with researchers within and outside of CARD. Requirements for the position include a strong background and extensive experience in neurodegenerative disease research and modern neuropathology. Preference will be given to those with demonstrated experience in digital pathology, the application of artificial intelligence to pathology and single cell-omics methods, as well as a strong track record of collaborative research.
Thematic area two: Translational research that aims to use functional genetics and/or genomics to translate knowledge of the genetic architecture of AD/ADRD to a biological understanding of disease processes. The successful candidate will launch an independent research program to determine the cellular context(s), risk alleles, effector genes, and mechanisms linked to known and to-be-discovered genetic risk loci for AD/ADRD. The position requires a strong background and extensive experience in neurogenetics, high-content genomics, and data science. There are growing genomic data resources from relevant individuals within CARD and the broader IRP and tissues for AD/ADRD including those aimed at revealing chromatin accessibility, chromatin organization, epigenetic marks, and transcriptional activity from brain, and single-cell populations. This rich unique resource will provide the opportunity to develop an independent research program. The successful applicant will also play a major role in expanding this resource, particularly in tissues and derived materials from underrepresented populations. The successful candidate will have a strong background and extensive experience in neurogenetics, high-content genomics, and the use of iPSC-derived cells and/or organoids as model systems. Preference will be given to those with demonstrated experience in neurodegeneration, and single-cell genomics, and with a strong track record of collaborative research.
The position includes an attractive start-up package and operating budget, including access to comprehensive NIA core facilities and to the unique and extensive resources of the NIH. Significant support will be available within CARD to enable data generation, discovery, analysis, and collaboration.
Eligible candidates must have a Ph.D. or M.D. (or M.D., Ph.D.) or equivalent doctoral degree in neuroscience, genetics, genomics, or related fields. The incumbent will play a major role in training staff and postdoctoral fellows and maintaining research continuity within CARD, as well as developing a network of intra- and extramural collaborations. The candidate’s capabilities must be demonstrated through publications in high-quality peer-reviewed journals in the relevant field(s). The incumbent is expected to demonstrate peer recognition of their specific contributions to these publications.
Salary is commensurate with experience and accomplishments. A full Civil Service package of benefits (including retirement, health, and life insurance, Thrift Savings Plan, etc.) is available. All employees of the Federal Government are subject to the conflict-of-interest statutes and regulations, including the Standards of Ethical Conduct. Additional information regarding CARD is available at the following website: https://www.nia.nih.gov/research/card.
To apply, please send a cover letter, curriculum vitae, and bibliography, a one-page mentoring and diversity impact statement, specifically detailing activities involving women and persons from other groups which are underrepresented in biomedical research, a statement of research interest (1-2 pages), and three letters of recommendation (sent directly from the letter writers) to Sarah Lewis, Supervisory Management Analyst, Office of the Scientific Director, National Institute on Aging; Vacancy #CARD-23-03-SL; via email: firstname.lastname@example.org. Applications, including letters of recommendation, must reference Vacancy #CARD-23-03-SL for consideration. The first round of reviews is expected to occur on or about September 18, 2023; however, applications will be accepted until the position is filled.
DHHS and NIH are Equal Opportunity Employers.
The NIH is dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.